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Avanafil is used for treating the problem of importance or erectile dysfunction in men. This drug is not meant for children or women.


It is important to remember that taking this medicine in combination with other drugs can lead to serious and sudden decrease in the level of blood pressure. If you are consuming any kind of nitrate drug, like nitroglycerin or medicines like Adempas, it is strictly recommended to avoid using Avanafil.


Sudden emergency situation like vision loss is quite possible when using Avanafil. In such a case, immediately stop taking the medicine and seek medical attention. Moreover, if the erection lasts for more than four hours or is painful, immediately get in touch with your healthcare provider because prolonged erection, also known as priapism can lead to severe damages to the tissues responsible for erection.


Action mechanism


Avanafil is known for being a selective PDE5 or phosphodiesterase 5 enzyme inhibitor that is used for treating erectile dysfunction caused by oxidative stress induced by your age, diabetes, and other complication. Moreover, it inhibits cGMP specific phosphodiesterase type 5 that is responsible for the degradation of cGMP in the corpus cavernosum located in the region around your penis. Erection of the penis during sexual stimulation is caused by the enhanced flow of blood in the penile region, resulting from penile arteries relaxation and the smooth muscle of the corpus cavernosal. The release of NO or nitric oxide from endothelial cells and nerves terminals is mediated by this response. This further stimulates the cGMP synthesis in smooth muscle cells. Moreover, cyclic GMP leads to the relaxation of smooth muscle cells and increases the flow of blood into the corpus cavernosum. The PDE5 inhibition by Avanafil enhances erectile function by simply enhancing the cGMP amount.


How to use this medication?


Avanafil is available in the form of oral tablets and should be taken with or without your meal. It is available in 200 mg, 50 mg, and 100 mg doses. This should be taken only 30 minutes before when you are feeling to have sex with your partner. Do not take this medicine more than once a day.


Your doctor can decrease or increase the dose depending on your medical condition and how you respond to this drug. You should clearly state your medical history, if any, to your physician in order to avoid any kind of potential side effects. If you have any uncomfortable feelings, immediately report to your physician without neglecting.


You are not allowed to take away when you have an allergic reaction to the ingredients present in it or have any of the following issues:


Consult with your physician if you have ever faced the following health problems:


  • Low level of blood pressure


  • Uncontrolled high blood pressure


  • Heart surgery


  • Stroke and heart attack


  • Heart rhythm disorder


  • Chest pain or angina


  • Heart failure


  • Stomach ulcer


  • Kidney and liver disease


  • If your doctor has asked you not to get involved sexual intercourse for your severe heart problems


  • Physical deformity of your penis like Peyronie’s disease


  • Priapism


  • Hearing problem


  • Bleeding issues


  • Retinitis pigmentosa


Moreover, this medication can easily reduce the flow of blood to the optic nerve present in your eyes. Thus, leads to a sudden loss of vision. This problem has been reported by a few people consuming Viagra or sildenafil as well as similar drugs like Avanafil. At the same time, this group of people also had diabetes, heart disease, high cholesterol, high blood pressure, a certain kind of pre-existing problems in the eyes as well as those who had the habit of smoking or over 50 years old. It is true that there is no clear evidence of Avanafil being responsible for vision loss.



Why available is just for men?


According to the studies it has been found that Avanafil is meant only for men because women’s’ bodies cannot absorb the ingredients present in it. Moreover, women who are breastfeeding or pregnant should not use this medicine at any cost.


How Avanafil is consumed?


It is important to follow all the directions given on your prescription as well as read the instructions sheets and medication guides. Your physician can change the dose occasionally to ensure that a particular dose does not become habituated to the body of a patient. Make sure that you consume the medication in the right process as directed to ensure the maximum possible benefits.


Overdosing and storing Avanafil


Just take this medicine once in 24 hours. Overdosing can lead to serious health effects including death. In case of emergency medical requirements, immediately get in touch with the professional physician. Avoid exposing the drug under direct sunlight. Always store it at room temperature, away from heat and light.


Shall I take extra doses? Missed dosage


Avanafil is used as needed, so there is no question of missing a dose. You just need to take one dose before getting into sexual activities with your partner. On the other hand, always avoid taking extra doses because it can lead to serious side effects. Stick to the recommended doses by your physician.




If you have a painful erection for an erection that lasts for more than 4 hours, immediately take a service of a healthcare provider because otherwise, it can damage the erection tissues surrounding your penis forever.


When should you take Avanafil?


It can be taken without or with your meal. This medicine is meant for using as and when required. Just take it 15 -30 minutes before indulging yourself in sexual activity. This drug can help you to get an erection when you are sexually stimulated. You need to understand that is pill is not meant for ultimate sexual pleasure. It should be taken only when you have the urge to have sex.


What do you need to avoid while consuming Avanafil?


Side effects of this drug can manifold with large alcohol consumption. If you are a regular alcohol drinker, make sure that you do not take more than 3 glasses while using Avanafil.


Moreover, grapefruit can interact severely with this medication, leading to severe and unwanted side effects. At the same time, also avoid using products that contain grapefruit.


Will Avanafil protective from HIV?


No, this medication is not going to protect you from any kind of sexually transmitted diseases, including AIDS and HIV. It is always suggested to use a condom to get the best protection while indulging in sexual activities.


What are the side effects of Avanafil?


You should always get immediate medical assistance when you see the signs of allergic reactions like breathing problems, hives, swelling of tongue, lips, and throat.


You should stop using this medication if you have blurry vision or face sudden vision loss.


During your sexual activities, if you feel nauseated or become dizzy, immediately stop and contact your health care provider. Numbness pain and tingling feeling in your make arms, chest, and jaw also need immediate medical assistance. The side effects of Avanafil can prove to be dangerous if proper and immediate medical care is not taken.


When should you stop using Avanafil?


Stop taking this medicine immediately and go for emergency medical help when you notice the following:


  • Penis erection which is lasting more than 4 hours or severely painful


  • Breathing shortness


  • A light-headed feeling, fainting


  • Warmth, swelling, redness, and pain in single or both legs


  • Hearing loss


  • Ringing in the ears


  • Sudden loss of vision


What are the common side effects of using this drug?


  • Cold symptoms like stuffy or runny nose


  • Headache


  • Back pain


  • Flushing, it includes a tingly feeling, redness, and warmth


Avanafil doses


Usual doses for adults for erectile dysfunction


Starting dose 


The initial dose is 100 mg and it should be take approximately half an hour before sexual activities


Maintenance dose


Well, 50 – 200 mg oral Avanafil should be taken half an hour before involving into sexual activities.


Maximum dose


200 mg oral Avanafil once per day


Drug interaction of Avanafil


It is suggested to avoid taking Avanafil with medicines of the similar group like Viagra, Verdenafil, Cialis, etc. These drugs have brand names Revatio, Adcirca, etc. that are used for treating pulmonary arterial hypertension.


You need to tell your physician about other drugs like,


  • Hepatitis C drugs – Telaprevir, Boceprevir, etc.


  • Antibiotics – Erythromycin, Clarithromycin, Telithromycin and etc.


  • Erectile dysfunction medicines


  • AIDS and HIV medicines – Atazanavir, Ritonavir, Indinavir, and Saquinavir


  • High blood pressure medicines for prostate disorder drugs – Silodosin, Alfuzosin, Doxazosin, Prazosin, Tamsulosin, Terazosin, etc.


  • Antifungal medication – Ketoconazole, Itraconazole, etc.


If you are taking Avanafil, make sure that you stay cautious about the side effects. Even if you feel that you are facing any of the aforementioned side effects, don’t wait, immediately contact your physician. It is necessary to stop using this drug at this stage because otherwise, the problem can rise to an incurable stage.

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